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Hyderabad: Dr. Seema Mishra, faculty of the Department of Biochemistry, School of Life Sciences, University of Hyderabad (UoH) has designed potential vaccine candidates, called T cell epitopes, against all the structural and non-structural proteins of novel coronavirus-2 (2019-nCoV) for experimental testing. Usually, vaccine discovery takes 15 years but the powerful computational tools helped in quickly enlisting these vaccine candidates in about 10 days. A ranked list of potential candidate vaccines, based on how effectively they will be used by human cells to stop the virus, has been generated. With no matches present in human protein pool, these coronaviral epitopes pose no cross-reactivity to human cells and hence, the immune response will be against viral proteins and not human proteins. These are the first such studies on nCoV vaccine design from India exploring whole coronaviral proteome across structural and non-structural proteins that make up the virus.
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