Animal experiments show diet change could reverse diabetes

  • By TOI
  • | Sunday | 12th November, 2017

JAIPUR: About 50 million people suffer from diabetes in India, sometimes referred to as 'diabetes capital of the world'. Now, research on animals has shown the condition could be treated with what is called 'very low calorie diet' (VLCD). The Yale-led team's study focused on understanding the mechanisms by which caloric restriction rapidly reverses type 2 diabetes," Science Daily reported.The team studied VLCD, consisting of one-quarter the normal intake, on a rodent model with type 2 diabetes. "In the liver, VLCD lowers glucose production by: 1) decreasing the conversion of lactate and amino acids into glucose; 2) decreasing the rate of liver glycogen conversion to glucose; and 3) decreasing fat content, which in turn improves the liver's response to insulin. "Reports indicate that the disease goes into remission in many patients who undergo bariatric weight-loss surgery, which significantly restricts caloric intake prior to clinically significant weight loss.


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