IIT Kharagpur identifies new areas of use for existing drugs

  • | Friday | 14th February, 2020

With blood disorders or hemoglobinopathies such as beta thalassemia and sickle cell anemia affecting millions, drug-induced increase in fetal hemoglobin has been shown to improve the condition of those affected with these blood disorders. However, as these drugs have side-effects, scientists are exploring if "repurposed" or existing drugs can be used to treat these disorders. As many as 19 miRNAs were found to be differentially expressed in those who had high fetal hemoglobin levels in their blood. For example, Valproate is used to treat seizure disorders in childhood and Vorinstat is an anticancer agent. An example is Sildenafil, which is used to treat impotence in males as well as neonatal pulmonary hypertension," said B.C.

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