Summary:
Previous research by Sanger scientists published in 2015 found that the H58 strain of typhoid first emerged in South Asia 25 to 30 years ago. Multi drug resistanceThe researcher found the bacterial strain causing the outbreak is now resistant to five antibiotics in total, more than seen in any outbreak before. more-inAn outbreak of typhoid fever in Pakistan is being caused by an extensively drug resistant "superbug” strain, a sign that treatment options for the bacterial disease are running out, scientists said on Tuesday. “This is the first time we have seen an outbreak of extensively drug-resistant typhoid,” said Elizabeth Klemm, who co-led the analysis work at the Sanger Institute. Researchers from Britain's Wellcome Sanger Institute who analysed the genetics of the typhoid strain found it had mutated and acquired an extra piece of DNA to become resistant to multiple antibiotics..