Chennai: While stressing the need to strengthen surveillance as well as upgrade vaccines against new variants even as people maintain mask discipline and physical distancing norm Principal Scientific Adviser to the Centre Prof K Vijay Raghavan has said a third wave of the Covid-19 pandemic is inevitable. Pointing to changes in the virus and the role of new variants with higher transmissibility and disease severity in the second wave he said “the pathogen has adopted hit and run tactics to breach the immunity many people developed during the first wave as also due to vaccination.” “A phase three (of Covid-19 pandemic) is inevitable given the high levels of circulating virus but it is not clear on what timescale this phase three will occur. Hopefully incrementally but we should prepare for new waves” according to Vijay Raghavan. The possibility could not be wished away as long as human hosts were available for infection and the only way to reduce this vulnerability was through safe practices and vaccination. Emphasising on the need to adapt Covid-appropriate behavior he said “The best time to change our behavior is now.” “What we do what we need to do does not change because of the virus. Masks and distancing are critical and most effective” he said. Infections and vaccinations are likely to cause adaptive pressure on the SARS-COV2 virus triggering new kind of changes he said. Scientific studies were on to examine likely alterations to tackle any upsurge in future. On why the second wave has been larger and much more severe Prof Vijay Raghavan said: “Phase 1 was a generalist approach of the virus and phase 2 now has fitter viruses arising due to post-immunity due to previous infection. Variants of concern represent better adaptation and are triggered by human population.” Assuring that the infections caused by new variants will plateau the principal scientific advisor cautioned that immune evasive variants and those which lower or increase disease severity will arrive in the future.

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